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9 min read

Ethics needs to catch-up with genetic innovation

Are we morally obliged to genetically edit?

John is Professor Emeritus of Cell and Molecular Biology at the University of Exeter.

An artistic visualisation of a DNA strand growing flowers from it.
Artist Nidia Dias visualises how AI could assist genomic studies.
Google Deepmind via Unsplash.

It makes me feel very old when I realise that Louise Brown, the first baby to be born via in vitro fertilisation (IVF), will be 47 years old on July 25th this year. Since her birth in 1978, over 10 million IVF-conceived babies have been born worldwide, of whom about 400,000 have been in the UK. Over that period, success rates have increased such that in some clinics, about 50 per cent of IVF cycles lead to a live birth. At the same time, there have also been significant advances in genetics, genomics and stem cell biology all of which, in relation to human embryos, raise interesting and sometimes challenging ethical issues. 

I start with a question: what is the ‘moral status’ of the early human embryo? Whether the embryo arises by normal fertilisation after sexual intercourse or by IVF, there is a phase of a few days during which the embryo is undergoing the earliest stages of development but has not yet implanted into the wall of the uterus; the prospective mother is not yet pregnant. In UK law, based on the Human Fertilisation and Embryology Act (1990), these early embryos are not regarded as human persons but nevertheless should be treated with some respect. Nevertheless, there are some who oppose this view and believe that from the ‘moment of conception’ (there actually isn’t such a thing – fertilisation takes several hours) embryos should be treated as persons. In ‘conventional’ IVF this debate is especially relevant to the spare embryos that are generated during each IVF cycle and which are stored, deep-frozen, in increasing numbers for possible use in the future.  

A further dimension was added to this area of debate when it became possible to test IVF embryos for the presence of genetic mutations that cause disease. This process is called pre-implantation genetic diagnosis and enables prospective parents who are at known risk of passing on a deleterious mutation to avoid having a child who possesses that mutation. But what about the embryos that are rejected? They are usually discarded or destroyed but some are used in research. However, those who hold a very conservative view of the status of the early embryo will ask what right we have to discard/destroy an embryo because it has the ‘wrong genes’. And even for the many who hold a less conservative view, there are still several questions which remain, including ‘which genetic variants we should be allowed to select against?; should we allow positive selection for genes known to promote health in some way?’; should we allow selection for non-therapeutic reasons, for example, sporting prowess?’ These questions will not go away and there are already indications that non-therapeutic selection is being offered in a small number of countries. 

Genetic modification 

This leads us on to think about altering human genes. Initially, the issue was genetic modification (GM) which in general involves adding genes. GM techniques have been used very successfully in curing several conditions, including congenital severe immune deficiency and as part of treatment programmes for certain very difficult childhood cancers. One key feature of these examples is that the genetic change is not passed on to the next generation – it just involves the body of someone who has already been born. Thus, we call them somatic genetic changes (from the Greek, sōmatikos, meaning ‘of the body’).  

Genetic modification which is passed on to the next generation is called germline GM which means that the genetic change must get into the ‘germ cells’, i.e., the sperm or egg. Currently, the only feasible way of doing this is to carry out the genetic modification on the very early embryo. At present however, with just one very specific exception, GM of human embryos is forbidden in all the countries where it would be possible to do it. There is firstly the question of deciding whether it is right to change the genetic makeup of a future human being in such a way that the change is passed to succeeding generations. Secondly, there are concerns about the long-term safety of the procedure. Although it would involve adding specific genes with known effects, the complexity of genetic regulation and gene interactions during human development means that scientist are concerned about the risks of unforeseen effects. And thirdly, germline GM emphasises dramatically the possibility of using GM for enhancement rather than for medical reasons.  

Genome editing 

This leads us to think about genome editing. In 2011, it was shown that a bacterial system which edits the genomes of invading viruses could also work in other organisms This opened up a large array of applications in research, agriculture and medicine. However, the ethical issues raised by genome editing are, in essence, the same as raised by GM and so there is still a universal prohibition of using the technique with human embryos: germline genome editing is forbidden. Despite this, a Chinese medical scientist, He Jiankui, announced in 2018 that he had edited the genomes of several embryos, making them resistant to HIV; two babies with edited genomes had already been born while several more were on the way. The announcement caused outrage across the world, including in China itself. He Jiankui was removed from his job and then, after a trial, was imprisoned for three years; his two colleagues who collaborated in this work received shorter sentences. 

At present the universal prohibition of human germline genome editing remains in place. However, the discussion has been re-opened in a paper by an Anglo-Australian group.  They suggest that we need to develop heritable (i.e. germline) polygenic genome editing in order to reduce significantly an individual's risk of developing degenerative diseases. These includecoronary artery disease, Alzheimer’s disease, major depressive disorder, diabetes and schizophrenia. I note in passing that one of the authors is Julian Savulescu at Oxford who is already well-known for his view that parents who are able to do so, are ‘morally obliged’ to seek to have genetically enhanced children, whether by PGD, GM or genome editing. The use of polygenic editing, which would, in all likelihood, be available only to the (wealthy) few, fits in well with his overall ethical position. Needless to say, the paper, published in the prestigious journal Nature, attracted a lot of attention in the world of medical genetics. It was not however, universally welcomed – far from it. Another international group of medical scientists and ethicists has stated that ‘Human embryo editing against disease is unsafe and unproven …’ and even go as far as to suggest that the technology is ‘… going to be taken up by people who are pushing a eugenics agenda …’ remain very pertinent. 

Harder still and harder 

I have no doubt that amongst different reader there will be a range of opinions about the topics discussed so far. For anyone who is Christian (or indeed an adherent of almost any religious faith), one of the difficulties is that modern science, technology and medicine have thrown up ethical questions that could not have even been dreamed of by the writers of the Bible (or of other religious texts). We just have to use our wisdom, knowledge and general moral compass (and for some, prayer) to try to reach a decision. And if what I have already written makes that difficult, some recent developments multiply that difficulty still more.  

In the early years of this century, scientists developed methods of transforming a range of human cells into ‘pluripotent’ stem cells, i.e., cells capable of growing into a wide range of cell types. It also became possible to get both induced stem cells and natural stem cells to develop into functional differentiated cells corresponding to specific body tissues. This has huge potential for repairing damaged organs. However, other applications are potentially much more controversial. In 2023, Cambridge scientists reported that they had used stem cells to create synthetic mouse embryos which progressed at least as far as brain and heart formation within the normal pattern of mouse embryo development. 

At about the same time, the Cambridge group used individual human embryonic stem cells (from the blastocyst stage of embryonic development), to ‘grow’ early human embryos in the lab. There is no intention to use these embryos to start a pregnancy – indeed, it would be illegal to do so – but instead to study a period of embryo development which is not permitted with ‘real’ human embryos (research must not continue past 14 days of development). But how should we regard synthetic embryos? What is their moral status? For those who hold a conservative view of the normal human embryo (see earlier), should we regard these synthetic embryos as persons? Neither does the law help us. The legal frameworks covering in vitro fertilisation and early embryos (Human Fertilisation and Embryology Acts, 1990, 2008) do not cover artificial embryos – they were unknown at the times the legislation was drawn up. Indeed, synthetic embryos/embryo models are, in law, not actually embryos, however much they look like/behave like early embryos. Earlier this month, the Human Fertilisation and Embryology Authority (HFEA) discussed these developments with a view to recommending new legislation, but this will not dispel an unease felt by some people, including the science correspondent of The Daily Telegraph, who wrote that this research is irresponsible.  

But there is more. In addition to synthetic embryos, the HFEA also discussed, the possible use of gametes – eggs and sperm – grown from somatic stem cells (e.g., from skin) in the lab. Some authors have suggested that the production of gametes in vitro is the ‘Holy Grail’ of fertility research. I am not so sure about that but it is clear that a lot of effort is going into this research. Success so far is limited to the birth of several baby mice, ‘conceived’ via lab-grown eggs and normal sperm. Nevertheless, it is predicted that lab-grown human eggs and sperm will be available within a decade. Indeed, several clinicians have suggested that these ‘IVGs’ (in vitro gametes) seem destined to become “a routine part of clinical practice”.  

The lab-grown gametes would be used in otherwise normal IVF procedures, the only novelty being the ‘history’ of the eggs and/or sperm. Clinicians have suggested that this could help couples in which one or both were unable to produce the relevant gamete, but who still wanted to have children. In this application, the use of IVGs poses no new ethical questions although we may be concerned about the possibility of the gametes carrying new genetic mutations. However, some of the more wide-ranging scenarios do at the least make us to stop and think. For example, it would be possible for a same-sex couple to have a child with both of them being a genetic parent (obviously for males, this would also involve a surrogate mother). More extremely, a person could have a child of which he or she was actually, in strictly genetic terms, both the ‘father’ and the ‘mother’. What are we to make of this? Where are our limits?  

Dr Christopher Wild, former director of International Agency for Research on Cancer, explores in depth many of the developments and issue I outlined above. His article on why a theology of embryos is needed, is clear, well-written, helpful and thought-provoking. 

 

This article is based on a longer blog post with full footnotes.  

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13 min read

In an age of nihilism it's time to revisit The Dark Knight

Batman, the Joker, and the disaffected

J.W. is a lecturer in the Study of Religions at the University of Oxford.

The Joker and Batman sit opposite each other in an interrogation room.
Warner Bros.

Christopher Nolan’s groundbreaking film The Dark Knight (2008), the second installment of his Batman trilogy, was a summer blockbuster that changed the superhero genre forever. Nolan’s gritty, realistic depiction of the Caped Crusader, played by a stoical Christian Bale, pushed back against the then nascent resurgence of comic-book cinema. Nolan resisted flashy computer-generated fight scenes and digitized superpowers in favor of psychological thrills intensified by cinematic restraint. The film’s combined financial and critical success empowered Nolan to become the preeminent big-budget auteur of Hollywood, going on to make such mind-benders as Inception (2010) and Interstellar (2014) and resurrecting the summer movie-going craze with the psychological biopic Oppenheimer (2023).  

The Dark Knight changed the way the superhero genre was perceived not only because of its realism and cinematic skill, but also—perhaps principally—because of the late Heath Ledger’s performance as the Joker, Batman’s premier antagonist and the main villain of the film. Ledger’s Joker was mythologized even before the film’s release, as the actor’s untimely death from a drug overdose in January 2008 was almost immediately credited by the media to the intensity of having inhabited the Joker’s personality. Of more lasting importance, Ledger’s Joker in many ways marked the first serious consideration of moral and political nihilism for a large audience. The villain put on the page by Nolan and brought to life by Ledger (in a posthumously Academy Award-winning performance) was at turns disturbing in its philosophical coherence and alluring in the authenticity with which the Joker lived his principles. Batman was the unambiguous “good guy,” but the Joker captivated the audience’s imagination. I can remember being a high schooler the year after the film’s release, and at every sporting event or dance party there were dozens of Joker faces in the crowd, with the signature white makeup and lipsticked smile. Never before had insanity been so attractive. For those of us raised in the suburban optimism of the 1990s, this was the first time that nihilism had become cool. 

In the wake of recent surges in political nihilism, though, ranging from online incel culture to a flurry of successful and attempted political assassinations to the January 6 capitol riots, it is perhaps worth revisiting the ideas considered by The Dark Knight nearly two decades after its release. Ours is a disaffected age, marked by despair at institutional incompetence and corruption on the one hand and a desire for a radical overhaul of justice on the other. As is often remarked, the predominant demographic of contemporary performative nihilism is millennial and Gen Z men, many of whom would have been old enough to see The Dark Knight in theaters but young enough to be profoundly impressionable to its ideas. It is not unreasonable to believe that the film acted as a foundational, if perhaps unconscious, philosophical education for whole generations coming of age in a cynical environment. Revisiting The Dark Knight today thus offers a potential lens on the sociopolitical challenges we face and the available philosophical and theological responses to them. 

Part of the Joker’s appeal comes from the audience’s upfront endorsement of extrajudicial justice. No one enjoys a superhero flick unless they are willing to suspend the state’s monopoly on righteous violence, at least for the duration of the film. The romance of the genre comes from getting to vicariously live the hero’s superseding of the limits of legality, which is legitimated by their superior sense of justice. We are meant to envy Batman’s vigilantism: even when the authorities come after him, he is always too crafty, too physically fit, and too technologically advanced for the bumbling police to handle. This contempt for the law is then assuaged for us by a vision of justice that actually effects the change for which we long. The vigilante movie depends on ends that clearly justify the means. 

Philosophical Joker 

Released in the summer of 2008, The Dark Knight would have spoken to a generation of youth raised on the cynicism of post-9/11 society and distrust of authority resulting from the interminable war in Iraq. Even as the film was entering theaters, the global financial crash was well underway, even if the majority of the public was as yet unaware of it, spurred on by government deregulation in favor of too-big-to-fail banks and their dubious financial exploitation of the middle class. The resulting economic downturn, amplified for millennials by ballooning student loan debt and the ineffectiveness of university degrees as a stepping-stone to quality employment, would in turn have elevated Batman’s appeal in the years after the film’s release. Unlike other superheroes whose power resides in abilities we can never possess, Batman’s fully human limitations and resourcefulness uniquely channel our anger into seemingly plausible solutions. (The film seems to recognize this, as a theme early on in the movie is Batman’s struggle to control less skilled copycats of his vigilante style.) Batman sanitizes our thirst for vengeance under the aegis of a higher justice.   

The effectiveness of the Joker as a philosophical villain, then, comes from the incisiveness with which he accurately diagnoses the inconsistencies in Batman’s arrangement with the law. In an early scene, the Joker attempts to make inroads with the mobsters of Gotham City. When their accountant flees to Hong Kong because it is beyond the jurisdiction of district attorney Harvey Dent, the Joker responds, “Batman has no jurisdiction. He’ll find him and make him squeal.” That Batman then predictably follows through on the Joker’s prediction—kidnapping the accountant with some spectacular escape artistry—is apparently no cause for the audience to question whether the Joker might be onto something.  

The Joker’s philosophy in many ways articulates Batman’s actions better than Batman’s own worldview. Batman wants to inspire the public to justice. But what he is in fact doing is undermining the legitimacy of the institutions charged with enforcing justice, implicitly endorsing anarchism as a necessary response to official corruption. Of course, the Joker doesn’t malign Batman for his contempt of corruption but only for his hypocrisy. In what amounts to his philosophical manifesto, toward the end of the film the Joker explains his worldview to a newly scarred and traumatized Dent, attempting to lure him into his orbit: 

They’re schemers. Schemers trying to control their little worlds. I’m not a schemer. I try to show the schemers how pathetic they’re attempts to control things really are… It’s the schemers that put you where you are. You were a schemer. You had plans. And look where that got you…  

You know what I’ve noticed? Nobody panics when things go ‘according to plan.’ Even if the plan is horrifying. If tomorrow I tell the press that, like, a gang-banger will get shot or a truckload of soldiers will be blown up, nobody panics. Because it’s all ‘part of the plan.’ But when I say that one little, old mayor will die, then everyone loses their minds! Introduce a little anarchy. Upset the established order, and everything becomes chaos. I’m an agent of chaos. Oh, and you know the thing about chaos? It’s fear. 

The Joker’s worldview, in a nutshell, is that evil is baked into the state’s attempts at control. No matter how hard they try, official authorities (governments, police, even churches) will never be able to enact real justice but only a mediocre shade of it. The compensation they provide is little more than a narrative to justify our collective misery and, if we’re lucky, a series of spectacles to distract us from our malaise.  

Ahead of the curve 

The Joker is in many ways a firm believer in existential freedom. Despite his apparent flippancy, he is the most serious character in the film, completely committed to his philosophy. The laughter and joy with which he carries out his heinous crimes is as much evidence of the ecstasies of genuine freedom as it is an indication of psychological disturbance. Contrary to the views of some, the Joker of Nolan and Ledger is not mentally ill. He is completely rational. He knows the human capacity for transcendence and finds civilization wanting as a vehicle for true human flourishing. He recognizes that we all know this to some extent, and he further recognizes that our primary motivation for denying our freedom is fear and convenience.  

During what is probably the film’s philosophical climax, Batman conducts an extrajudicial interrogation of the Joker. In a profound twist, it is the Joker who is the more rational of the two characters in this scene, accurately diagnosing the unacknowledged dark side of Batman’s ideology while the ostensibly self-disciplined hero spirals into ever more erratic violence. Derisively comparing Batman to official law enforcement, often maligned throughout the film as variously corrupt or incompetent, the Joker says:  

Don’t talk like one of them—you’re not, even if you’d like to be. To them you’re just a freak. Like me. They need you right now. But when they don’t, they’ll cast you out like a leper. See, their morals, their code: it’s a bad joke. Dropped at the first sign of trouble. They’re only as good as the world allows them to be. I’ll show you. When the chips are down, these ‘civilized’ people, they’ll eat each other. See, I’m not a monster. I’m just ahead of the curve. 

In one fell swoop, the Joker has indicted both Batman and the establishment. If we side with the government, then we accept hypocrisy and ineffectiveness as the cost of a milquetoast justice. A grown adult fighting crime in a mask is freakish and absurd, nothing more than fantastical escapism. It is better to fall in line and get over your ideals. But if we instead take the side of Batman, then we have already cleared the greatest hurdle to embracing the Joker’s monstrosity. 

The righteous Batman 

Batman’s justice is derived from his single principle not to kill. He is constrained by neither ideological mercy nor legal precedent but only his own conscience. Yet as the Joker points out, once a vigilante has decided that their own justice is sufficient to discard the law, there is little to stop them from forsaking rules altogether: “The only sensible way to live in this world is without rules. And tonight you’re gonna break your one rule.” Batman understandably becomes more violent as the dialogue continues, exposing the dark side of his extralegal sense of justice. Pummeling the Joker in the interrogation room, Batman becomes a villain in his own right, enacting the Joker’s plan to perfection. The Joker wants Batman to kill him, if only because then the Joker’s triumph will be complete. One thinks here of Obi-Wan’s statement to Darth Vader in Star Wars (1977): “If you strike me down, I shall become more powerful than you can possibly imagine.” Or the final scene in V for Vendetta (2005): “Behind this mask there is an idea. And ideas are bulletproof.” The Joker’s philosophy is not proved by the superiority of his own strength but by his ability to lure even the most righteous figures into the abyss. Once stated, his diagnosis becomes a self-fulfilling prophecy. In his own words at the film’s finale, “Madness, as you know, is like gravity. All it takes is a little push.” From the first time he donned the mask, Batman had entered the realm of nihilism. The Joker is simply pointing this out and trying to get him to follow through to vigilantism’s natural conclusion.  

In his ideological war with Batman, the Joker’s final trick is consequently to turn Gotham City into a madhouse. If the general public caves to fear and begins to tear itself apart, then the Joker’s assessment of human nature will be proved correct. In the film, Batman is justified, first by the civilians and prisoners who collectively choose not to blow up each other’s boats with the Joker’s explosives (perhaps more out of cowardice than idealism) and then by his decision to personally take the blame for Harvey Dent’s murderous rampage in order to preserve Dent’s inspiring figure for the public. Whether or not these constitute real victories is debatable, but the film ends by willing us to believe that Batman’s worldview is not inconceivable for average folks like us. In an obviously Christlike swap, Batman is so righteous that he is even willing to take the consequences of the corrupted sinner on himself in order to redeem both the sinner and the public who needs him as their hero. 

But with the contemporary proliferation of illiberal ideology, the dissemination of myriad conspiracy theories, and the surge in political violence in the years since The Dark Knight’s release, we may have cause to reassess the outcome of this ideological battle. Has Batman or the Joker more accurately grasped the modern public’s psyche? Is it the Joker or the film’s optimistic finale that is spinning a fantasy?  

Jesus and The Joker 

From the Christian perspective, the question is nuanced but not necessarily answered. The Jesus of the gospels is by turns vigilantist, nihilistic, and neither. He is at some moments indifferent to the state—as when he endorses paying taxes to Caesar while unambiguously discounting money as having any real value—and at other times openly hostile, as when he challenges King Herod as a schemer in the mode of the Joker’s own critique. He self-consciously transcends the law without abolishing it. The entire Sermon on the Mount endorses a view of justice that goes beyond what could ever be meted out by law or reasonably enforced by institutions. Jesus is even willing to engage in some raging guerilla theatre to expose corrupt institutional authorities, and he frequently lambasts legalist hypocrites for preaching an ideology inconsistent with their practice. 

If I had to stake my own interpretation, I would aver that the Jesus portrayed in the New Testament is closer to the Joker’s nihilism than to Batman’s vigilantism, both in his own behavior and the model he endorses for others. Of course, Jesus’ pacifism differs immensely from the murderous Joker. The Joker wants to make a point through the expense of human life. For Jesus, abundant human life is itself the point. Jesus forgives his persecutors from the cross and condemns violence as a response to injustice. But what Jesus and the Joker both fundamentally agree upon is the inadequacy of institutional channels for true justice. Batman might agree in principle, but his view of justice is plagued by internal contradictions: He abandons the law while seeking to uphold it; he forsakes legal constraint while encoding justice in specific principles.  

What the Joker gets right from the Christian perspective, even if he never says so, is that genuine flourishing is incompatible with legal framing. Spontaneity, play, and delight are essential to human freedom. The Joker exemplifies this, even if his joy is perversely tethered to violence. What the Joker desires is evil, but he effectively illustrates how law devoid of desire cannot amount to justice.  

For Jesus, true justice consistently comes down to love, which is nothing if not rooted in desire. The only motivation to turn the other cheek, pray for your enemies, or give all your possessions to the poor is because you truly desire to do so. Such extreme acts of charity are absurd by the standards of the social contract. Transcending social and legal expectations can have no motivation other than desire. Gratuity, in the sense of both an unmerited gift and ridiculous excess, is the defining feature of Jesus’ ethic. This comes through most profoundly in Jesus’ metaphors for the Kingdom of God: a weed that grows like crazy, a pound of yeast in fifty pounds of flour, an economy where everyone gets paid the same regardless of merit. We need to remember that Jesus attracted the kind of followers who walked off good-paying jobs and abandoned their boats on a whim. The Joker has just the right amount of insanity to be a Christian, even if he misses the key ingredient of love.  

This sketch of a classic film and the character of Jesus is not enough to provide a coherent ethical program. But that is precisely not the point. The attempt to narrowly codify justice is what Jesus and the Joker both call out for hypocrisy, and it’s the thing that sends Batman spiraling through contradictions. If we are to properly respond to the nihilism that surrounds us online and in our politics today, then we first need to appreciate the credibility of the nihilistic diagnosis of contemporary life. This does not mean conceding to the despair that leads to hatred and violence. If anything, the life and teachings of Jesus illustrate something akin to a post-nihilistic doctrine of love. Just as resurrection requires death, so answering nihilism might require passing through it rather than ignoring its existence. Like Batman, Jesus insists that true justice is realizable for all of us. Like the Joker, though, Jesus understands that this requires a leap into the absurd. We cannot love until we can play, when we burst the bounds of cultural norms and the status quo. We will be truly just only when we find the freedom to go beyond what is required and chart a new frontier, when we learn to jump out of the boat and wager our sanity on the absurd.  

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