Review
Aliens
Culture
Film & TV
7 min read

The problem with The Three Body Problem

The possibility of love in a universe of terror.
a man leans against one end of a table one another sits against its other end.
Two bodies contemplate a problem.
Netflix.

If you are prone to nightmares or paranoia you might want to steer clear of the first season of Netflix’s sci-fi epic, 3 Body Problem. Adapted from Cixin Liu’s multi award-winning Remembrance of Earth’s Past trilogy, the story starts in the Chinese Cultural revolution of the 1960s and ends twelve million years in the future. Mercifully the narrative is non-linear, so we’re spared a minute-by-minute account. It begins as a global mystery - scientists all over the planet are taking their own lives in mysterious circumstances – and ends with advanced alien weaponry collapsing the universe to a single dimension. All based on a true story, apparently. 

Why the paranoia? At the heart of both Liu’s novels and the Netflix adaption, is a particularly terrifying solution to the Fermi Paradox. Enrico Fermi was one of the physicists working on the Manhattan Project (played by Danny Defari in the Christopher Nolan depiction of it in Oppenheimer), who presented his now famous paradox to his colleagues at Los Almos. The paradox goes like this: in a galaxy of billions of stars similar to our sun it is almost certain that advanced alien life is out there, and yet we have not received any convincing evidence of their existence. This, it seems, requires some explanation. 

Interestingly, this question was also the starting point of C.S. Lewis’ sci-fi cycle The Cosmic Trilogy, and lies behind the title of its first book, Out of the Silent Planet. According to Lewis, the Earth has been placed under a kind of galactic quarantine, as a result of the fall of humanity, nothing and no-one is allowed in or out. The solar system is teeming with life, but we are partitioned from it. We’ve been blocked from the cosmic WhatsApp group for breaching behaviour standards. The aliens are out there but they’re keeping clear. We are the silent planet. 

Cixin Liu however opts for a darker and more disturbing solution to Fermi’s question, which provides the title of the second book in his trilogy, The Dark Forest. The aliens are out there, but it is not we who have been silenced, it is they who are silent. The universe, according to this theory, is like a forest filled with predators and the most sensible thing any intelligent life can do is hide in the undergrowth to avoid attracting attention. Telegraphing our existence into the void by sending signals into space is to naively invite destruction. Alerting the universe to our presence is an act of existential self-harm. The universe is silent because everyone is hiding. For Lewis the universe shone with a love from which we had been excluded, for Liu it is saturated with malice from which we should exclude ourselves. 

If Nietzsche was right, that we can survive any how as long as we have a why, then Liu’s characters are saddled with the opposite burden: endless hows and no why. 

It probably isn’t too much of a spoiler to acknowledge that the inevitable happens. Aliens are contacted. They do make plans to invade.  It is arguably a bit more of spoiler to give away exactly how this happens. The distance between them and us is so vast that, even travelling at one percent lightspeed it will take their invasion fleet four hundred years to get here. And in the meantime, just to ensure we can’t mount any meaningful defence against them, they fold a planet-sized computer into a photon-sized particle and send it to earth to sabotage all technological development. They can watch our every movement, overhear every conversation. We know they are coming and can do almost nothing about it. The bodies of suicides hanging in the fog from every lamppost lining the Thames underline the overriding despair. It is deliciously bleak. I did not sleep well after watching it. 

Liu’s brilliance is not in doubt. The Netflix adaptation can barely capture the fireworks of creative inventiveness that crowd every page of his books (indeed the producers even dropped the definitive article from the book's title). In China, his fellow science fiction writers simply call him ‘Da Liu’ (Big Liu) in honour of his works of towering imagination. But I can’t help feeling that the overall atmosphere of The Three Body Problem is an example of what the theologian Carver Yu, another Chinese author, claimed characterised our culture: technological optimism and literary despair. Liu’s characters respond to the relentless encroachment of a malevolent universe with endless technological innovation. They possess an inexplicable will to survive in a cosmos where no one would wish to live. If Nietzsche was right, that we can survive any how as long as we have a why, then Liu’s characters are saddled with the opposite burden: endless hows and no why. They are thirsting for purpose while drowning in applications.  

What struck me most watching the Netflix adaptation was that it seemed to extend the experience of living in a post-industrial society to the whole universe. Our sense that many of the organisations to which we owe our allegiance are clever but inhuman, technologically advanced yet amoral, is expanded to fill the farthest reaches of our imagination. Of course, human beings have always done this. Our ancestors saw faces in the clouds and gods in the constellations. We peer into the emptiness of the skies and populate them with our fears and hopes. Faced with the Copernican revolution and the rise of science, Pascal anticipated the cosmic horror of Liu by nearly four hundred years in confessing, ‘the eternal silence of these infinite spaces fills me with dread.’ The Three Body Problem, unlike Lewis who saw planet Earth as an aberration in an otherwise benevolent cosmos, takes our global technological arms-race and makes it the ultimate reality of the entire universe. 

The crucial point is that we are not obliged to populate the blank canvas of the cosmos with the malice of Liu or the terror of Pascal.

The Three Body Problem then, like much science fiction, is a valuable and ingenious thought-experiment, but not one I wish to dwell on for too long. I prefer to contrast it with something closer to the cosmology that informed C.S. Lewis. One in which the core operating principle of everything is not the necessity of violence, but the indispensability of love. Something akin to Teilhard de Chardin’s assertion that in the dreams, wonder, exploration and imagination of love, a thread is woven that reaches the very heart of the universe. Despite all appearances to the contrary, love is the deepest reality of all.  

This assertion is problematic in many ways. Not least in the face of the evident brutality and violence that traumatises human life. But even more fundamentally than that, how can we intelligibly assert the primacy of love while gazing out at a vast indifferent universe? What are we to do with those infinite silent spaces that so terrorised Pascal? 

Perhaps we can try another thought-experiment. This one is drawn from the work of philosopher Chris Barrigar. He calls it the Agape/Probability account. The full argument is long and detailed, so there is no time to explain it all, but the broad brushstrokes are enough. Here’s the thought. What if we live in exactly the kind of universe required to produce creatures who can freely choose to live with self-giving love? They couldn’t be forced or coerced into it, but the conditions could be set in place that would lead to the emergence of such beings. The principles of ‘asymptotic’ statistics suggest that some things may not be determined but they can be so highly probable as to be inevitable. Barrigar asserts that the appearance of a species with the capacity to love was a cosmic inevitability. What is required to turn this possibility into something pretty much certain? Two things – lots of opportunities and lots of time. In other words, with apologies to Carl Sagan, if we want creatures capable of love, we need to build a universe. 

Of course, a universe like that – a universe like ours – will throw up many other things in addition to love: violence, rock music and apples pies. But the crucial point is that we are not obliged to populate the blank canvas of the cosmos with the malice of Liu or the terror of Pascal. The cold silence of space does not in itself contradict our intuitive sense that the capacity to love is somehow ultimately significant. On the contrary, when we look at the vast distances between the stars, we could be looking at the minimal amount of spaciousness required to bring about beings with the capacity for self-giving love. At the very least, it’s a thought-experiment worth trying. 

Explainer
Biology
Culture
Ethics
9 min read

Ethics needs to catch-up with genetic innovation

Are we morally obliged to genetically edit?

John is Professor Emeritus of Cell and Molecular Biology at the University of Exeter.

An artistic visualisation of a DNA strand growing flowers from it.
Artist Nidia Dias visualises how AI could assist genomic studies.
Google Deepmind via Unsplash.

It makes me feel very old when I realise that Louise Brown, the first baby to be born via in vitro fertilisation (IVF), will be 47 years old on July 25th this year. Since her birth in 1978, over 10 million IVF-conceived babies have been born worldwide, of whom about 400,000 have been in the UK. Over that period, success rates have increased such that in some clinics, about 50 per cent of IVF cycles lead to a live birth. At the same time, there have also been significant advances in genetics, genomics and stem cell biology all of which, in relation to human embryos, raise interesting and sometimes challenging ethical issues. 

I start with a question: what is the ‘moral status’ of the early human embryo? Whether the embryo arises by normal fertilisation after sexual intercourse or by IVF, there is a phase of a few days during which the embryo is undergoing the earliest stages of development but has not yet implanted into the wall of the uterus; the prospective mother is not yet pregnant. In UK law, based on the Human Fertilisation and Embryology Act (1990), these early embryos are not regarded as human persons but nevertheless should be treated with some respect. Nevertheless, there are some who oppose this view and believe that from the ‘moment of conception’ (there actually isn’t such a thing – fertilisation takes several hours) embryos should be treated as persons. In ‘conventional’ IVF this debate is especially relevant to the spare embryos that are generated during each IVF cycle and which are stored, deep-frozen, in increasing numbers for possible use in the future.  

A further dimension was added to this area of debate when it became possible to test IVF embryos for the presence of genetic mutations that cause disease. This process is called pre-implantation genetic diagnosis and enables prospective parents who are at known risk of passing on a deleterious mutation to avoid having a child who possesses that mutation. But what about the embryos that are rejected? They are usually discarded or destroyed but some are used in research. However, those who hold a very conservative view of the status of the early embryo will ask what right we have to discard/destroy an embryo because it has the ‘wrong genes’. And even for the many who hold a less conservative view, there are still several questions which remain, including ‘which genetic variants we should be allowed to select against?; should we allow positive selection for genes known to promote health in some way?’; should we allow selection for non-therapeutic reasons, for example, sporting prowess?’ These questions will not go away and there are already indications that non-therapeutic selection is being offered in a small number of countries. 

Genetic modification 

This leads us on to think about altering human genes. Initially, the issue was genetic modification (GM) which in general involves adding genes. GM techniques have been used very successfully in curing several conditions, including congenital severe immune deficiency and as part of treatment programmes for certain very difficult childhood cancers. One key feature of these examples is that the genetic change is not passed on to the next generation – it just involves the body of someone who has already been born. Thus, we call them somatic genetic changes (from the Greek, sōmatikos, meaning ‘of the body’).  

Genetic modification which is passed on to the next generation is called germline GM which means that the genetic change must get into the ‘germ cells’, i.e., the sperm or egg. Currently, the only feasible way of doing this is to carry out the genetic modification on the very early embryo. At present however, with just one very specific exception, GM of human embryos is forbidden in all the countries where it would be possible to do it. There is firstly the question of deciding whether it is right to change the genetic makeup of a future human being in such a way that the change is passed to succeeding generations. Secondly, there are concerns about the long-term safety of the procedure. Although it would involve adding specific genes with known effects, the complexity of genetic regulation and gene interactions during human development means that scientist are concerned about the risks of unforeseen effects. And thirdly, germline GM emphasises dramatically the possibility of using GM for enhancement rather than for medical reasons.  

Genome editing 

This leads us to think about genome editing. In 2011, it was shown that a bacterial system which edits the genomes of invading viruses could also work in other organisms This opened up a large array of applications in research, agriculture and medicine. However, the ethical issues raised by genome editing are, in essence, the same as raised by GM and so there is still a universal prohibition of using the technique with human embryos: germline genome editing is forbidden. Despite this, a Chinese medical scientist, He Jiankui, announced in 2018 that he had edited the genomes of several embryos, making them resistant to HIV; two babies with edited genomes had already been born while several more were on the way. The announcement caused outrage across the world, including in China itself. He Jiankui was removed from his job and then, after a trial, was imprisoned for three years; his two colleagues who collaborated in this work received shorter sentences. 

At present the universal prohibition of human germline genome editing remains in place. However, the discussion has been re-opened in a paper by an Anglo-Australian group.  They suggest that we need to develop heritable (i.e. germline) polygenic genome editing in order to reduce significantly an individual's risk of developing degenerative diseases. These includecoronary artery disease, Alzheimer’s disease, major depressive disorder, diabetes and schizophrenia. I note in passing that one of the authors is Julian Savulescu at Oxford who is already well-known for his view that parents who are able to do so, are ‘morally obliged’ to seek to have genetically enhanced children, whether by PGD, GM or genome editing. The use of polygenic editing, which would, in all likelihood, be available only to the (wealthy) few, fits in well with his overall ethical position. Needless to say, the paper, published in the prestigious journal Nature, attracted a lot of attention in the world of medical genetics. It was not however, universally welcomed – far from it. Another international group of medical scientists and ethicists has stated that ‘Human embryo editing against disease is unsafe and unproven …’ and even go as far as to suggest that the technology is ‘… going to be taken up by people who are pushing a eugenics agenda …’ remain very pertinent. 

Harder still and harder 

I have no doubt that amongst different reader there will be a range of opinions about the topics discussed so far. For anyone who is Christian (or indeed an adherent of almost any religious faith), one of the difficulties is that modern science, technology and medicine have thrown up ethical questions that could not have even been dreamed of by the writers of the Bible (or of other religious texts). We just have to use our wisdom, knowledge and general moral compass (and for some, prayer) to try to reach a decision. And if what I have already written makes that difficult, some recent developments multiply that difficulty still more.  

In the early years of this century, scientists developed methods of transforming a range of human cells into ‘pluripotent’ stem cells, i.e., cells capable of growing into a wide range of cell types. It also became possible to get both induced stem cells and natural stem cells to develop into functional differentiated cells corresponding to specific body tissues. This has huge potential for repairing damaged organs. However, other applications are potentially much more controversial. In 2023, Cambridge scientists reported that they had used stem cells to create synthetic mouse embryos which progressed at least as far as brain and heart formation within the normal pattern of mouse embryo development. 

At about the same time, the Cambridge group used individual human embryonic stem cells (from the blastocyst stage of embryonic development), to ‘grow’ early human embryos in the lab. There is no intention to use these embryos to start a pregnancy – indeed, it would be illegal to do so – but instead to study a period of embryo development which is not permitted with ‘real’ human embryos (research must not continue past 14 days of development). But how should we regard synthetic embryos? What is their moral status? For those who hold a conservative view of the normal human embryo (see earlier), should we regard these synthetic embryos as persons? Neither does the law help us. The legal frameworks covering in vitro fertilisation and early embryos (Human Fertilisation and Embryology Acts, 1990, 2008) do not cover artificial embryos – they were unknown at the times the legislation was drawn up. Indeed, synthetic embryos/embryo models are, in law, not actually embryos, however much they look like/behave like early embryos. Earlier this month, the Human Fertilisation and Embryology Authority (HFEA) discussed these developments with a view to recommending new legislation, but this will not dispel an unease felt by some people, including the science correspondent of The Daily Telegraph, who wrote that this research is irresponsible.  

But there is more. In addition to synthetic embryos, the HFEA also discussed, the possible use of gametes – eggs and sperm – grown from somatic stem cells (e.g., from skin) in the lab. Some authors have suggested that the production of gametes in vitro is the ‘Holy Grail’ of fertility research. I am not so sure about that but it is clear that a lot of effort is going into this research. Success so far is limited to the birth of several baby mice, ‘conceived’ via lab-grown eggs and normal sperm. Nevertheless, it is predicted that lab-grown human eggs and sperm will be available within a decade. Indeed, several clinicians have suggested that these ‘IVGs’ (in vitro gametes) seem destined to become “a routine part of clinical practice”.  

The lab-grown gametes would be used in otherwise normal IVF procedures, the only novelty being the ‘history’ of the eggs and/or sperm. Clinicians have suggested that this could help couples in which one or both were unable to produce the relevant gamete, but who still wanted to have children. In this application, the use of IVGs poses no new ethical questions although we may be concerned about the possibility of the gametes carrying new genetic mutations. However, some of the more wide-ranging scenarios do at the least make us to stop and think. For example, it would be possible for a same-sex couple to have a child with both of them being a genetic parent (obviously for males, this would also involve a surrogate mother). More extremely, a person could have a child of which he or she was actually, in strictly genetic terms, both the ‘father’ and the ‘mother’. What are we to make of this? Where are our limits?  

Dr Christopher Wild, former director of International Agency for Research on Cancer, explores in depth many of the developments and issue I outlined above. His article on why a theology of embryos is needed, is clear, well-written, helpful and thought-provoking. 

 

This article is based on a longer blog post with full footnotes.  

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