The heart of the matter

Heart doctor Michael Henein steps back to consider the unseen and unique wonders of the human body’s design.

Michael Henein

Professor Michael Henein is a consultant cardiologist, and a Professor of Cardiology at Umea University, Sweden.

A model of a human heart on a short stand.

Photo by Jesse Orrico on Unsplash.

Shakespeare famously asked:

“What a piece of work is a man, how noble in reason, how
infinite in faculties, in form and moving how express and admirable, in action how like an angel, in apprehension how like a god! the beauty of the world, the paragon of animals—and yet, to me, what is this quintessence of dust?

Humans may be complex, capable of great heroism and deep depravity, yet it is worth stopping for a moment to look at the human body and mind to marvel in what we have become, and how we are made.

The visible design of the human body points out common features shared along with other members of the animal kingdom. Examples of these features are: two eyes, two ears, two nostrils, one mouth and four limbs, attached to a body and head. Detailed study of different seen parts of the body may, however, show some differences. For example, the presence of fingers and nails, hair distribution as well as a developed tail. While most members of the animal kingdom have teeth and a tongue, those two could also vary in their number and size, respectively, according to different species. Genetic investigations have shown that we humans share 99 % of our genes with animals, suggesting that our “earthly” component shares a common origin. Indeed, the twenty first century scientific findings match what is written in the Genesis story of creation, a story written over 3,500 years ago, well before genetic sciences came to light.

Creatures great and small

As for morphological differences between animal species, it is difficult to naively conclude why some are wild while others are man-friendly-even if the wild ones have different shapes, design, dietary habits, body size and life span. Other important observed features of the members of the animal kingdom are that they are all born, they all age, then ultimately die.

If we are to look at the unseen features of the members of the animal kingdom, we can again identify similarities. For example, all have a gastrointestinal tract, a cardiovascular system, a reproductive system, a respiratory system, a urinary system and much more. While these systems may differ slightly between species, the overall structure and function achieve similar purposes. For example, heart speed is faster in small animals like rats compared to big ones like elephants who have very slow hearts. Likewise, the respiratory system and the number of respiratory cycles per minute are significantly faster in running animals compared to the sedentary and slowly moving ones. Finally, the number of offspring also differs in different species, being just one at a time in big animals like elephants and horses, and many offspring in small animals like rabbits and mice. Such paradox between the number of offspring and animal size makes you think of the important determining role of the activity of those animals.

Unseen wonders

Now to turn to the rest of the animal kingdom and the unseen features of the human body. To start, let us look at the amazing functions of the human brain and its various functions. When humanity is sometimes described as the crown of creation, such a description is based on the superiority of human brain function and skills. Its sophisticated structure and how vital centres are created deep in the skull, to be protected from traumas, make you marvel. Also, the brain controls the different functions of the whole body, with its sensory and motor activities, various vital system functions including the lungs and the heart, all endocrine glands’ function, in addition to various receptors and centres that allow utmost precision and accuracy in everything we do. An example of this kind of precision is a doctor feeling a vein or an artery with the tip of a finger to insert a needle or a musician moving a finger a few millimetres while playing a violin, to produce the exact sound needed. Furthermore, the integrated function of human muscles, nerves and spinal cord is also amazing, let alone the synapsis between the nerve endings and muscle bundles, the chemicals secreted in them which allow electric stimulus transmission from the nervous system to achieve the motor function and desired movement.

The human brain also has the unique feature of storing knowledge. Of course, we should not ignore the importance of the training and programming ability of human brain. We learn how to drive a car, how to play games, how to study, how to operate safely on a sick patient. Such acquired skills are quite limited in other members of the animal kingdom. Moreover, the human brain has the unique ability to invent, discover, improve and correct errors it identifies.

Another very unique feature of human brain is its ability to conduct speech, a feature of humans that is under-developed in other members of the animal kingdom. While most animals can make noise and sounds, only humans can articulate words, sentences and even sing very complex songs. This unique ability seems to be the underlying mechanism behind the development of languages which are based on the human ability to talk and transmit information and knowledge by words and phrases.

The unseen brain has allowed human life to develop over time, building skills and achievements from generation to generation. Millennia ago, humans lived in huts together with animals, and now they build houses and palaces to live in. Centuries ago, we used donkeys, horses and camels to travel but now we use cars, trains, ships and airplanes. Our ancestors burned wood and coal to cook and to warm but now we use electricity to do these.

When we look carefully at the unseen parts of the human body, we also realize that we cannot alter any of it, despite the scientific advances made over the years. We can understand what harms our body and take measures to avoid it. Out of the ability of our brain to discover and invent, we have now produced science-based means for curing various diseases. Consider how we can replace a dysfunctional heart valve or a mobility-limiting joint. These inventions have resulted in a better quality of life, alleviating of symptoms, even helping to avoid early death, in some cases such as heart disease and cancer.

The heart of the matter

Another unseen source of life in humans is the heart. This fist-size organ is so complex in its structure and function. Recent scientific advances have enabled us to study heart function in milliseconds, hence the development of pacemaker treatments. They have also allowed clear imaging of the inside of the heart and the identification of pathologies, developments that guide practitioners to the optimum treatment of heart conditions. Recent discoveries have also allowed us to better understand how people develop coronary artery disease and how the pathology starts at the innermost layer of the arteries, particularly in individuals carrying significant risks for atherosclerosis including, smoking, high blood pressure, diabetes, high cholesterol and obesity. Amazingly, obesity has been shown to be the strongest underlying cause of other risk factors, hypertension, diabetes and hypercholesterolemia. So, nature cannot be blamed in many of these patients but our own patterns of behaviour. Science has shown that walking at least 5,000 steps each day, complying with the design of our body, reduces the likelihood of developing coronary artery disease by 15 per cent.

The unseen physiology of the rest of our body systems and the interaction between systems make us wonder how we are made. A rise of our body temperature by one degree due to a bug infection affects all body systems from the brain to the heart. A virus which cannot be seen by the most powerful microscope can destroy our lungs and cause premature death, as was the case with COVID-19 and others.

Finally, human inventions in the form of powerful microscopes have allowed scientists to study the human cell, which is the smallest living component of our body. Such small cells cannot be replicated in any factory in the twenty-first century, despite the vast scientific developments that surround us. You'll be surprised to learn how complicated and meticulously fine-tuned a human cell is and also how it functions, connects with other cells and other parts of the body. An example of this is the interaction between body minerals, calcium, sodium and potassium with heart and muscle individual cells. Such a function is critically controlled by many factors such as time, electric stimulation and pressure differences producing remarkably harmonious contractions and relaxation of the muscles without missing a beat.

Review

Art

Awe and wonder

Culture

16 July 2025

5 min read

This gallery refresh adds drama to the story of art

Rehanging the Sainsbury Wing revives the emotion of great art

Jonathan Evens

Jonathan is Team Rector for Wickford and Runwell. He is co-author of The Secret Chord, and writes on the arts.

An art gallery arch reveals a suspended crucifix and other paintings in a distant room

The Sainsbury Wing interior.

The Sainsbury Wing of the National Gallery has recently reopened after closure for two years for building works. There was controversy over the designs for the Sainsbury Wing in the planning stage but its use, once built, to tell the story of the early stages in the development of Western art was widely welcomed and appreciated.

The story that it told is essentially the story of Christian art and so the reopening of the Sainsbury Wing together with the rehanging of the National Gallery’s collection provides an opportunity to review that story. As a result of the completed work over 1,000 works of art - a larger proportion of the collection than has been previously displayed - trace the development of painting in the Western European tradition from the 13th to the 20th centuries from beloved favourites to paintings never previously seen in the National Gallery.

The Sainsbury Wing features works from the medieval and Renaissance periods. Painting came of age during this time. It moved from manuscript illumination to images on panel and canvas, overtaking metalwork, tapestry and sculpture as the most popular and prestigious art form in Europe.

An opening room contains works from the 14th to the 16th centuries, including The Wilton Diptych and Leonardo Da Vinci’s The Virgin of the Rocks, which together ask visitors to consider the full spectrum of what painting can do. This introductory room gives a sense of what these paintings were for and how they were used. Painting’s rise in status was due to all the things it can do such as tell complex stories, convey human emotions, fool the eye, capture a likeness, make viewers laugh, weep, pray and think. This room provides a sample of those achievements and the various functions painting fulfilled.

Throughout the Sainsbury Wing, new display cases are used to show paintings as objects viewed from all sides, not simply as flat panels on walls. Medieval altarpieces often had winged panels that could be opened or closed depending on the season or occasion. An example is included here to show how such hinged panels were used.

From this introductory room spanning the period, visitors can follow either a Northern European route or Italian route around the space, enabling influences between both to be highlighted. The key change explored on both routes is that artists in this period began to create a convincing illusion of reality in their paintings.

The earliest paintings in the National Gallery Collection were made in central Italy nearly 800 years ago. These naturalistic and intimate images of love, grief and suffering responded to a new interest in the humanity of Christ. A chapel-like space is entirely dedicated to Piero della Francesca whose work, with its cool colour palette and keen sense of space and light, possesses a dignified solemnity. Another room focuses on the spiritual power of gold-ground scenes of devotion, exploring the way gold in paintings was used to evoke the timeless, spiritual significance of Christ, the Virgin and saints, and set these holy figures apart from our world.

The galleries in the Sainsbury Wing were designed to evoke, for visitors, a Renaissance Basilica. Its architectural features make it possible to display paintings in a similar way to how they would have originally been encountered. The central galleries form the nave of the basilica and all the altarpieces displayed are now there. These galleries are devoted to works made in Florence, Venice, and Siena. The early Florentine room represents the principal point of departure for this new art. In the Venetian room we see the development of perspective, while the Siena room resembles a side chapel in the basilica.

An altarpiece made for the church of San Pier Maggiore in Florence by Jacopo di Cione and his workshop has been reconstructed and sits on an altar-like plinth to evoke the view of it originally seen by worshippers. Predella panels by Fra Angelico are displayed in a case in front of this altarpiece giving an indication of the way in which predellas interacted with a larger, grander altarpiece. The positioning of these two works also illustrates the movement in terms of realism found in the paintings of this period. The Ascension scene on the altarpiece depicts a statue-like ascended Christ while Fra Angelico’s resurrected Christ in the predella is more realistically floating in the air.

In a first for the National Gallery, Segna di Bonaventura’s Crucifix is visible down the central spine of the Sainsbury Wing, suspended from the ceiling. This enables today’s audiences to view the work in the way it would have been seen in the 14th century. Painted crucifixes were common in 13th- and 14th-century Italian churches, often displayed high-up like this one. Rood screens on which such crucifixes were originally placed were often destroyed in the Counter Reformation, which led to crucifix’s then being hung from the ceiling, as is the case here.

The rehang also presents several works back on display after long-term conservation projects. The Martyrdom of Saint Sebastian by Antonio del Pollaiuolo and Piero del Pollaiuolo is back on show after nearly three years of conservation and scientific examination.

The rehang of The Sainsbury Wing brings to life the way artists forged a new way of painting, painting with a drama that no one had seen before.

Despite the religious and political upheaval caused by the Reformation, the arts also flourished in Northern Europe during this time. Prints transformed the exchange of artistic ideas. Christians were encouraged to use images as a focus for meditation on the lives of Christ and the saints and paintings that were meant to be handled and examined close-up were created for the private devotion of members of religious orders and laypeople. Albrecht Dürer and Lucas Cranach were key figures, with Dürer’s prints, portraits, altarpieces and non-religious subjects transforming painting both in the Holy Roman Empire and beyond.

Christianity became the predominant power shaping European culture after classical antiquity, inspiring artists and patrons to evoke the nature of sacred mysteries in visual terms. The rehang of The Sainsbury Wing brings to life the way artists forged a new way of painting, painting with a drama that no one had seen before and with stories flowing across panels in colourful scenes. These displays also promote a greater understanding of how works of art were, and still are, used as models of moral behaviour, as celebrations of the deeds of holy figures or as a plea for one’s hopes, both in this life and in the afterlife.

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