Essay
Culture
Music
5 min read

Strangers and the sound of belonging

Utterly captivated by a clip of a Jacob Collier concert, and then immediately intrigued by said captivation, Belle Tindall wonders why thousands of strangers singing together has been eliciting such a powerful reaction.

Belle is the staff writer at Seen & Unseen and co-host of its Re-enchanting podcast.

A muscian plays a keyboard on a concert stage surrounded by instruments, while multiple images of his face are projected behind him.
Jacob Collier in concert.
Jon Tilkin, CC BY-SA 4.0, via Wikimedia Commons.

I had an empty couple of minutes to play with; so, mostly due to muscle memory, I found myself opening my Instagram app. Habitually, I do this multiple times a day, and mostly to no profound avail. But this one day, something caught my eye and sent me down a spiral of curiosity (and judging by how astronomically viral it went, it seems I was not spiralling alone).  

It was footage of Jacob Collier performing in Rome. Jacob is a singer, songwriter, jazz instrumentalist and general music prodigy. But that’s not the most captivating thing about him. The Collier phenomena has erupted because of the way he turns his audience of strangers into a perfectly tuned, beautifully united, choir. And this particular night in Rome, he managed to steer this audience to sing beyond the major scale and onto the far more complex chromatic scale, something he has been working towards for years.  

The most striking thing about this minute-long clip is not the beautifully raw sound (although, it really is something to behold), but what this sound is communicating - a tangible sense of belonging.

Watch Jacob Collier in Rome

Our need to belong

We each know how it feels to belong, and we are also acutely aware of the inverse, how it feels when a sense of belonging is lacking, and feelings of isolation creep in and make themselves at home in its absence. But for the sake of clarity, perhaps a working definition would be helpful at this point, and for that, I turn to the Psychology Dictionary. The PD defines ‘belonging’ as ‘a feeling of being taken in and accepted as part of a group, thus, fostering a sense of belonging. It also relates to being approved of and accepted by society in general. Also called belongingness.’  

The notion of ‘belonging,’ or ‘belongingness,’ has been well studied. And still, its intrinsic power is staggering to consider.  

According to research published by the Australian Journal of Psychology, belonging is a universal and fundamental human need, one that ‘may just be as important as food, shelter, and physical safety’. So intrinsic is it, that the lack of belonging, resulting in acute loneliness, is attributed to a 26% increase in the risk of premature mortality. This has led the World Health Organisation to officially recognise isolation as a determinant of health, placing it in the same category as smoking, physical inactivity, and excessive alcohol consumption. 

Further research suggests that our brains perceive, and subsequently react to, social pain in the same way they are designed to react to physical pain. Releasing opioids and other instinctive painkillers when encountering a lack of belonging, our brains are detecting literal pain within us. As humans, we are susceptible to suffering social injuries, and it seems that the subconscious parts of our brains take those injuries much more seriously than their conscious counterparts.  

The necessity of belonging is woven into our make-up.

Subsequently, when we speak of a person’s need to belong, we’re speaking of a need that has significant mental, emotional, spiritual, behavioural, and physical repercussions; a need that is intersectional, if you will. It is a central construct at the core of our humanity and a defining variable in how we perceive reality.  

It could be suggested, considering all of this, that human beings were simply made to belong. The necessity of belonging is woven into our make-up. 

Surrounded by people versus belonging with people  

Over the final scene of the 2009 film World’s Greatest Dad, Robin Williams’ voice delivers a line that is so profound it lingers in your mind long after the end-credits have finished rolling. He says ‘I used to think the worst thing in life would be to end up all alone. It’s not. The worst thing in life is to end up with people who make you feel alone.’   

There’s a staggering wisdom in that.  

Namely, that belonging is not the inevitable outcome of simply getting people into one room. That’s the difference between the Collier concert - where the audience are truly belonging to each other, if only for an evening - and the coffee shop where I’m sitting right now, filled with people using laptops and headphones as a form of defence against the threat of small talk. Each of us belonging only to ourselves.  

If it were the case that proximity equated to belonging, urbanization and the subsequent squeezing of populations into close quarters would have surely deterred the epidemic of loneliness that the West currently finds itself in. And yet, it is not uncommon for ‘neighbour’ and ‘stranger’ to be identities that co-exist. And what about the role of social media? Access to one another has never been so readily available. The world has never been so small, and its population so ‘close.’ And yet, what social media so often provides is the affirmation and amplification of feelings of isolation.  

No. Proximity alone is not the answer.  

Will Van Der Hart writes that ‘People don’t just want to be with other people they want to belong with them’. 

The tuning fork

Christianity has a lot to say on the subject of belonging/belongingness.  

The anonymous author of the creation literature (the chapters which act as the start-line for the Biblical narrative) notes how the only thing that was unsatisfactory about our freshly created world was the initial isolation of humanity. Such solitude was at odds with the blueprint for human flourishing and defied our design as intrinsically relational beings. The Christian faith therefore offers an explanation to humanity’s fundamental need to belong, It presents a spiritual why behind the afore-mentioned neurological findings.  

The biblical narratives, the psychological research – they are united (if you pardon the pun) in their assessment of the human condition. Namely, that belonging is simply a non-negotiable, it’s buried inside our biology. 

So, perhaps it’s no wonder Jacob Collier has caught the world’s attention, he’s providing a simple soundtrack to one of our most engrained needs. It seems that what has long been communicated through ancient spiritual texts and more recently affirmed through endless psychological theories, can also be communicated with a simple harmonious sound.   

To watch that clip is to watch thousands of strangers belong: belong to the room, belong to the moment, belong to the sound. 

In 1948, author and theologian, A.W Tozer pondered the nature of unity and human connection. He asked, ‘has it ever occurred to you that one hundred pianos all tuned to the same fork are automatically tuned to each other?’ 

If ever we were looking for an answer to this profound question, we need look no further than Jacob Collier’s audience and their sound of belonging.   

Explainer
Biology
Culture
Ethics
9 min read

Ethics needs to catch-up with genetic innovation

Are we morally obliged to genetically edit?

John is Professor Emeritus of Cell and Molecular Biology at the University of Exeter.

An artistic visualisation of a DNA strand growing flowers from it.
Artist Nidia Dias visualises how AI could assist genomic studies.
Google Deepmind via Unsplash.

It makes me feel very old when I realise that Louise Brown, the first baby to be born via in vitro fertilisation (IVF), will be 47 years old on July 25th this year. Since her birth in 1978, over 10 million IVF-conceived babies have been born worldwide, of whom about 400,000 have been in the UK. Over that period, success rates have increased such that in some clinics, about 50 per cent of IVF cycles lead to a live birth. At the same time, there have also been significant advances in genetics, genomics and stem cell biology all of which, in relation to human embryos, raise interesting and sometimes challenging ethical issues. 

I start with a question: what is the ‘moral status’ of the early human embryo? Whether the embryo arises by normal fertilisation after sexual intercourse or by IVF, there is a phase of a few days during which the embryo is undergoing the earliest stages of development but has not yet implanted into the wall of the uterus; the prospective mother is not yet pregnant. In UK law, based on the Human Fertilisation and Embryology Act (1990), these early embryos are not regarded as human persons but nevertheless should be treated with some respect. Nevertheless, there are some who oppose this view and believe that from the ‘moment of conception’ (there actually isn’t such a thing – fertilisation takes several hours) embryos should be treated as persons. In ‘conventional’ IVF this debate is especially relevant to the spare embryos that are generated during each IVF cycle and which are stored, deep-frozen, in increasing numbers for possible use in the future.  

A further dimension was added to this area of debate when it became possible to test IVF embryos for the presence of genetic mutations that cause disease. This process is called pre-implantation genetic diagnosis and enables prospective parents who are at known risk of passing on a deleterious mutation to avoid having a child who possesses that mutation. But what about the embryos that are rejected? They are usually discarded or destroyed but some are used in research. However, those who hold a very conservative view of the status of the early embryo will ask what right we have to discard/destroy an embryo because it has the ‘wrong genes’. And even for the many who hold a less conservative view, there are still several questions which remain, including ‘which genetic variants we should be allowed to select against?; should we allow positive selection for genes known to promote health in some way?’; should we allow selection for non-therapeutic reasons, for example, sporting prowess?’ These questions will not go away and there are already indications that non-therapeutic selection is being offered in a small number of countries. 

Genetic modification 

This leads us on to think about altering human genes. Initially, the issue was genetic modification (GM) which in general involves adding genes. GM techniques have been used very successfully in curing several conditions, including congenital severe immune deficiency and as part of treatment programmes for certain very difficult childhood cancers. One key feature of these examples is that the genetic change is not passed on to the next generation – it just involves the body of someone who has already been born. Thus, we call them somatic genetic changes (from the Greek, sōmatikos, meaning ‘of the body’).  

Genetic modification which is passed on to the next generation is called germline GM which means that the genetic change must get into the ‘germ cells’, i.e., the sperm or egg. Currently, the only feasible way of doing this is to carry out the genetic modification on the very early embryo. At present however, with just one very specific exception, GM of human embryos is forbidden in all the countries where it would be possible to do it. There is firstly the question of deciding whether it is right to change the genetic makeup of a future human being in such a way that the change is passed to succeeding generations. Secondly, there are concerns about the long-term safety of the procedure. Although it would involve adding specific genes with known effects, the complexity of genetic regulation and gene interactions during human development means that scientist are concerned about the risks of unforeseen effects. And thirdly, germline GM emphasises dramatically the possibility of using GM for enhancement rather than for medical reasons.  

Genome editing 

This leads us to think about genome editing. In 2011, it was shown that a bacterial system which edits the genomes of invading viruses could also work in other organisms This opened up a large array of applications in research, agriculture and medicine. However, the ethical issues raised by genome editing are, in essence, the same as raised by GM and so there is still a universal prohibition of using the technique with human embryos: germline genome editing is forbidden. Despite this, a Chinese medical scientist, He Jiankui, announced in 2018 that he had edited the genomes of several embryos, making them resistant to HIV; two babies with edited genomes had already been born while several more were on the way. The announcement caused outrage across the world, including in China itself. He Jiankui was removed from his job and then, after a trial, was imprisoned for three years; his two colleagues who collaborated in this work received shorter sentences. 

At present the universal prohibition of human germline genome editing remains in place. However, the discussion has been re-opened in a paper by an Anglo-Australian group.  They suggest that we need to develop heritable (i.e. germline) polygenic genome editing in order to reduce significantly an individual's risk of developing degenerative diseases. These includecoronary artery disease, Alzheimer’s disease, major depressive disorder, diabetes and schizophrenia. I note in passing that one of the authors is Julian Savulescu at Oxford who is already well-known for his view that parents who are able to do so, are ‘morally obliged’ to seek to have genetically enhanced children, whether by PGD, GM or genome editing. The use of polygenic editing, which would, in all likelihood, be available only to the (wealthy) few, fits in well with his overall ethical position. Needless to say, the paper, published in the prestigious journal Nature, attracted a lot of attention in the world of medical genetics. It was not however, universally welcomed – far from it. Another international group of medical scientists and ethicists has stated that ‘Human embryo editing against disease is unsafe and unproven …’ and even go as far as to suggest that the technology is ‘… going to be taken up by people who are pushing a eugenics agenda …’ remain very pertinent. 

Harder still and harder 

I have no doubt that amongst different reader there will be a range of opinions about the topics discussed so far. For anyone who is Christian (or indeed an adherent of almost any religious faith), one of the difficulties is that modern science, technology and medicine have thrown up ethical questions that could not have even been dreamed of by the writers of the Bible (or of other religious texts). We just have to use our wisdom, knowledge and general moral compass (and for some, prayer) to try to reach a decision. And if what I have already written makes that difficult, some recent developments multiply that difficulty still more.  

In the early years of this century, scientists developed methods of transforming a range of human cells into ‘pluripotent’ stem cells, i.e., cells capable of growing into a wide range of cell types. It also became possible to get both induced stem cells and natural stem cells to develop into functional differentiated cells corresponding to specific body tissues. This has huge potential for repairing damaged organs. However, other applications are potentially much more controversial. In 2023, Cambridge scientists reported that they had used stem cells to create synthetic mouse embryos which progressed at least as far as brain and heart formation within the normal pattern of mouse embryo development. 

At about the same time, the Cambridge group used individual human embryonic stem cells (from the blastocyst stage of embryonic development), to ‘grow’ early human embryos in the lab. There is no intention to use these embryos to start a pregnancy – indeed, it would be illegal to do so – but instead to study a period of embryo development which is not permitted with ‘real’ human embryos (research must not continue past 14 days of development). But how should we regard synthetic embryos? What is their moral status? For those who hold a conservative view of the normal human embryo (see earlier), should we regard these synthetic embryos as persons? Neither does the law help us. The legal frameworks covering in vitro fertilisation and early embryos (Human Fertilisation and Embryology Acts, 1990, 2008) do not cover artificial embryos – they were unknown at the times the legislation was drawn up. Indeed, synthetic embryos/embryo models are, in law, not actually embryos, however much they look like/behave like early embryos. Earlier this month, the Human Fertilisation and Embryology Authority (HFEA) discussed these developments with a view to recommending new legislation, but this will not dispel an unease felt by some people, including the science correspondent of The Daily Telegraph, who wrote that this research is irresponsible.  

But there is more. In addition to synthetic embryos, the HFEA also discussed, the possible use of gametes – eggs and sperm – grown from somatic stem cells (e.g., from skin) in the lab. Some authors have suggested that the production of gametes in vitro is the ‘Holy Grail’ of fertility research. I am not so sure about that but it is clear that a lot of effort is going into this research. Success so far is limited to the birth of several baby mice, ‘conceived’ via lab-grown eggs and normal sperm. Nevertheless, it is predicted that lab-grown human eggs and sperm will be available within a decade. Indeed, several clinicians have suggested that these ‘IVGs’ (in vitro gametes) seem destined to become “a routine part of clinical practice”.  

The lab-grown gametes would be used in otherwise normal IVF procedures, the only novelty being the ‘history’ of the eggs and/or sperm. Clinicians have suggested that this could help couples in which one or both were unable to produce the relevant gamete, but who still wanted to have children. In this application, the use of IVGs poses no new ethical questions although we may be concerned about the possibility of the gametes carrying new genetic mutations. However, some of the more wide-ranging scenarios do at the least make us to stop and think. For example, it would be possible for a same-sex couple to have a child with both of them being a genetic parent (obviously for males, this would also involve a surrogate mother). More extremely, a person could have a child of which he or she was actually, in strictly genetic terms, both the ‘father’ and the ‘mother’. What are we to make of this? Where are our limits?  

Dr Christopher Wild, former director of International Agency for Research on Cancer, explores in depth many of the developments and issue I outlined above. His article on why a theology of embryos is needed, is clear, well-written, helpful and thought-provoking. 

 

This article is based on a longer blog post with full footnotes.  

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