Review

Books

Culture

Politics

9 April 2025

4 min read

Is it OK to pray for the death of a dictator?

What happens when the mighty lose their thrones.

Simon Burton-Jones

Simon is Bishop of Tonbridge in the Diocese of Rochester. He writes regularly round social, cultural and political issues.

Bullet holes on a wall and white paint outlines mark the site of an execution

The wall where Nicolae and Elena Ceausescu were executed.

NPR.

The end, when it comes, can be nasty, brutish and filmed.

Muammar Gaddafi, self-styled Brotherly Leader and Guide of the Revolution, spent the last moments of his life cowering in a Libyan sewer after an air strike on his convoy. On discovery, a mob subjected him to some ghastly final abuses before death – the kind of ending he had mercilessly condemned thousands to. It was almost biblical in its parabola, and it was recorded on a wobbly camera.

But it was not the first of its kind in this generation. On Christmas Day 1989, the disfigured face of Nicolae Ceausescu was broadcast on TV following his summary execution by hastily assembled opposition forces in Romania. Only days previously, he had been an unassailable dictator.

Vladimir Putin has spoken about Gaddafi’s ending, and it clearly troubles him, but perhaps Ceausescu’s death is lodged in the dark recesses of his mind because it was the one bloody end of all the communist leaders of eastern Europe.

Being a dictator is an all-consuming job. Too many domestic and foreign enemies are made along the way for the dictator to drop their vigilance. And their downfall often comes at the hands of those closest to them; by definition, these people know the dictator’s movements and weaknesses better than others and are best placed to exploit them. The military must be equipped to suppress dissent, but give it too much power and the generals pose a risk to the dictator. Yet if the military lacks the hardware, control of the population becomes harder. Many dictators surround themselves with specially trained loyal guards to defend against the military, but the rule of terror means no-one speaks the honest truth and so risks appear everywhere. No wonder dictators are usually paranoid and themselves racked with the fear that a culture of capricious violence induces in everyone.

These and other theories are explored by Marcel Dirsus in his compelling book How Tyrants Fall (John Murray, 2025). Dirsus notes how dictators require money, weapons and people to survive in office and for the elites around them to believe these goods will remain in place. They also need to immerse the surrounding elites in blood guilt, so that their fate becomes entwined with the dictator’s; Saddam Hussein compelled others to join him in the murder and execution of opponents.

For Dirsus, there are two ways to topple a tyrant. The most direct is to take them out, but this is rarely straightforward. Coup attempts are often shambolic in their planning and even well-orchestrated ones usually fail; the consequences for those implicated are always horrendous. The second route is patient and pragmatic, looking to weaken the tyrant, strengthen alternative elites and empower the masses. External powers often have minimal influence unless, like the US in Iraq, the country is invaded and the tyrant deposed. Sanctions often fail to hurt the elites; a state’s geographic proximity to the tyrant’s nation can be useful, as it gives a base from which opponents of the regime can work.

Modern technology is changing the face of political action, making it easier for large groups to mobilise against regimes, as seen in the short-lived Arab Spring. It also enables dictators to track opponents more successfully than even the feared Stasi in East Germany. Right now, it feels like the tyrants are ahead in this game.

Shortly after the full-scale Russian invasion of Ukraine in February 2022, a friend said to me that he was praying for Putin’s death or downfall. I asked him how sure he was that the person who replaced Putin would be better. If the pragmatic route for toppling a dictator involves strengthening different elites and empowering the masses, the likelihood is that the elites will take over, not the masses. Dictators never allow the components of civil society to form; democratic institutions take decades to build. And they rarely anoint successors in advance, for fear alternative power bases are created. When dictators fall, it usually leads to initial chaos and violence before another elite can establish itself from which a new dictator will emerge.

In her inspired song of praise at the news she would give birth to the long-awaited Messiah, Mary observes how God ‘has brought down the powerful from their thrones and lifted up the lowly’. It is a role reversal typical of St Luke, recorder of Mary’s song, a gift of eschatology many want realised today, not just in the world to come. When the powerful are brought down from their throne today, they are typically replaced by the next most powerful person, and if the throne remains vacant or is contested, what follows often feels like the spirit that went out of a person in Matthew Gospel returning with seven other spirits more evil than itself, meaning ‘the last state of person is worse than the first’.

This need not be a counsel of despair, but a call to informed intercessory prayer which is short on controlling advice for God’s geo-political strategy, and long on the wisdom and patience of the one throne that endures.

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Explainer

Biology

Culture

Ethics

7 March 2025

9 min read

Ethics needs to catch-up with genetic innovation

Are we morally obliged to genetically edit?

John Bryant

John is Professor Emeritus of Cell and Molecular Biology at the University of Exeter.

An artistic visualisation of a DNA strand growing flowers from it.

Artist Nidia Dias visualises how AI could assist genomic studies.

Google Deepmind via Unsplash.

It makes me feel very old when I realise that Louise Brown, the first baby to be born via in vitro fertilisation (IVF), will be 47 years old on July 25th this year. Since her birth in 1978, over 10 million IVF-conceived babies have been born worldwide, of whom about 400,000 have been in the UK. Over that period, success rates have increased such that in some clinics, about 50 per cent of IVF cycles lead to a live birth. At the same time, there have also been significant advances in genetics, genomics and stem cell biology all of which, in relation to human embryos, raise interesting and sometimes challenging ethical issues.

I start with a question: what is the ‘moral status’ of the early human embryo? Whether the embryo arises by normal fertilisation after sexual intercourse or by IVF, there is a phase of a few days during which the embryo is undergoing the earliest stages of development but has not yet implanted into the wall of the uterus; the prospective mother is not yet pregnant. In UK law, based on the Human Fertilisation and Embryology Act (1990), these early embryos are not regarded as human persons but nevertheless should be treated with some respect. Nevertheless, there are some who oppose this view and believe that from the ‘moment of conception’ (there actually isn’t such a thing – fertilisation takes several hours) embryos should be treated as persons. In ‘conventional’ IVF this debate is especially relevant to the spare embryos that are generated during each IVF cycle and which are stored, deep-frozen, in increasing numbers for possible use in the future.

A further dimension was added to this area of debate when it became possible to test IVF embryos for the presence of genetic mutations that cause disease. This process is called pre-implantation genetic diagnosis and enables prospective parents who are at known risk of passing on a deleterious mutation to avoid having a child who possesses that mutation. But what about the embryos that are rejected? They are usually discarded or destroyed but some are used in research. However, those who hold a very conservative view of the status of the early embryo will ask what right we have to discard/destroy an embryo because it has the ‘wrong genes’. And even for the many who hold a less conservative view, there are still several questions which remain, including ‘which genetic variants we should be allowed to select against?; should we allow positive selection for genes known to promote health in some way?’; should we allow selection for non-therapeutic reasons, for example, sporting prowess?’ These questions will not go away and there are already indications that non-therapeutic selection is being offered in a small number of countries.

Genetic modification

This leads us on to think about altering human genes. Initially, the issue was genetic modification (GM) which in general involves adding genes. GM techniques have been used very successfully in curing several conditions, including congenital severe immune deficiency and as part of treatment programmes for certain very difficult childhood cancers. One key feature of these examples is that the genetic change is not passed on to the next generation – it just involves the body of someone who has already been born. Thus, we call them somatic genetic changes (from the Greek, sōmatikos, meaning ‘of the body’).

Genetic modification which is passed on to the next generation is called germline GM which means that the genetic change must get into the ‘germ cells’, i.e., the sperm or egg. Currently, the only feasible way of doing this is to carry out the genetic modification on the very early embryo. At present however, with just one very specific exception, GM of human embryos is forbidden in all the countries where it would be possible to do it. There is firstly the question of deciding whether it is right to change the genetic makeup of a future human being in such a way that the change is passed to succeeding generations. Secondly, there are concerns about the long-term safety of the procedure. Although it would involve adding specific genes with known effects, the complexity of genetic regulation and gene interactions during human development means that scientist are concerned about the risks of unforeseen effects. And thirdly, germline GM emphasises dramatically the possibility of using GM for enhancement rather than for medical reasons.

Genome editing

This leads us to think about genome editing. In 2011, it was shown that a bacterial system which edits the genomes of invading viruses could also work in other organisms This opened up a large array of applications in research, agriculture and medicine. However, the ethical issues raised by genome editing are, in essence, the same as raised by GM and so there is still a universal prohibition of using the technique with human embryos: germline genome editing is forbidden. Despite this, a Chinese medical scientist, He Jiankui, announced in 2018 that he had edited the genomes of several embryos, making them resistant to HIV; two babies with edited genomes had already been born while several more were on the way. The announcement caused outrage across the world, including in China itself. He Jiankui was removed from his job and then, after a trial, was imprisoned for three years; his two colleagues who collaborated in this work received shorter sentences.

At present the universal prohibition of human germline genome editing remains in place. However, the discussion has been re-opened in a paper by an Anglo-Australian group. They suggest that we need to develop heritable (i.e. germline) polygenic genome editing in order to reduce significantly an individual's risk of developing degenerative diseases. These includecoronary artery disease, Alzheimer’s disease, major depressive disorder, diabetes and schizophrenia. I note in passing that one of the authors is Julian Savulescu at Oxford who is already well-known for his view that parents who are able to do so, are ‘morally obliged’ to seek to have genetically enhanced children, whether by PGD, GM or genome editing. The use of polygenic editing, which would, in all likelihood, be available only to the (wealthy) few, fits in well with his overall ethical position. Needless to say, the paper, published in the prestigious journal Nature, attracted a lot of attention in the world of medical genetics. It was not however, universally welcomed – far from it. Another international group of medical scientists and ethicists has stated that ‘Human embryo editing against disease is unsafe and unproven …’ and even go as far as to suggest that the technology is ‘… going to be taken up by people who are pushing a eugenics agenda …’ remain very pertinent.

Harder still and harder

I have no doubt that amongst different reader there will be a range of opinions about the topics discussed so far. For anyone who is Christian (or indeed an adherent of almost any religious faith), one of the difficulties is that modern science, technology and medicine have thrown up ethical questions that could not have even been dreamed of by the writers of the Bible (or of other religious texts). We just have to use our wisdom, knowledge and general moral compass (and for some, prayer) to try to reach a decision. And if what I have already written makes that difficult, some recent developments multiply that difficulty still more.

In the early years of this century, scientists developed methods of transforming a range of human cells into ‘pluripotent’ stem cells, i.e., cells capable of growing into a wide range of cell types. It also became possible to get both induced stem cells and natural stem cells to develop into functional differentiated cells corresponding to specific body tissues. This has huge potential for repairing damaged organs. However, other applications are potentially much more controversial. In 2023, Cambridge scientists reported that they had used stem cells to create synthetic mouse embryos which progressed at least as far as brain and heart formation within the normal pattern of mouse embryo development.

At about the same time, the Cambridge group used individual human embryonic stem cells (from the blastocyst stage of embryonic development), to ‘grow’ early human embryos in the lab. There is no intention to use these embryos to start a pregnancy – indeed, it would be illegal to do so – but instead to study a period of embryo development which is not permitted with ‘real’ human embryos (research must not continue past 14 days of development). But how should we regard synthetic embryos? What is their moral status? For those who hold a conservative view of the normal human embryo (see earlier), should we regard these synthetic embryos as persons? Neither does the law help us. The legal frameworks covering in vitro fertilisation and early embryos (Human Fertilisation and Embryology Acts, 1990, 2008) do not cover artificial embryos – they were unknown at the times the legislation was drawn up. Indeed, synthetic embryos/embryo models are, in law, not actually embryos, however much they look like/behave like early embryos. Earlier this month, the Human Fertilisation and Embryology Authority (HFEA) discussed these developments with a view to recommending new legislation, but this will not dispel an unease felt by some people, including the science correspondent of The Daily Telegraph, who wrote that this research is irresponsible.

But there is more. In addition to synthetic embryos, the HFEA also discussed, the possible use of gametes – eggs and sperm – grown from somatic stem cells (e.g., from skin) in the lab. Some authors have suggested that the production of gametes in vitro is the ‘Holy Grail’ of fertility research. I am not so sure about that but it is clear that a lot of effort is going into this research. Success so far is limited to the birth of several baby mice, ‘conceived’ via lab-grown eggs and normal sperm. Nevertheless, it is predicted that lab-grown human eggs and sperm will be available within a decade. Indeed, several clinicians have suggested that these ‘IVGs’ (in vitro gametes) seem destined to become “a routine part of clinical practice”.

The lab-grown gametes would be used in otherwise normal IVF procedures, the only novelty being the ‘history’ of the eggs and/or sperm. Clinicians have suggested that this could help couples in which one or both were unable to produce the relevant gamete, but who still wanted to have children. In this application, the use of IVGs poses no new ethical questions although we may be concerned about the possibility of the gametes carrying new genetic mutations. However, some of the more wide-ranging scenarios do at the least make us to stop and think. For example, it would be possible for a same-sex couple to have a child with both of them being a genetic parent (obviously for males, this would also involve a surrogate mother). More extremely, a person could have a child of which he or she was actually, in strictly genetic terms, both the ‘father’ and the ‘mother’. What are we to make of this? Where are our limits?

Dr Christopher Wild, former director of International Agency for Research on Cancer, explores in depth many of the developments and issue I outlined above. His article on why a theology of embryos is needed, is clear, well-written, helpful and thought-provoking.

This article is based on a longer blog post with full footnotes.

John Bryant's Blog

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